Migraine and headache

Published human studies in migraine and headache.

This page lists published studies. It reports what the authors did and found, with the limits of each study. It is not advice.

6 studies listed, newest first.

• Fixed combination of palmitoylethanolamide and melatonin in preventive therapy of migraine: results from a randomized clinical trial
  Piccolo V et al. · Frontiers in Nutrition · 2025
  Randomised controlled trialHumansWith melatonin
• Effectiveness of Palmitoylethanolamide (Levagen+) Compared to a Placebo for Reducing Pain, Duration, and Medication Use during Migraines in Otherwise Healthy Participants—A Double-Blind Randomised Controlled Study
  Briskey D et al. · Pharmaceuticals · 2024
  Randomised controlled trialHumans
• Palmitoylethanolamide-based nutraceutical Calmux in preventive treatment of migraine
  Gonzalez Hernandez A · Clinical Neurology and Neurosurgery · 2022
  Open-label, no control groupHumans
• Spinal nociceptive sensitization and plasma palmitoylethanolamide levels during experimentally induced migraine attacks
  De Icco R et al. · Pain · 2021
  Controlled trialHumans
• Tolerability of Palmitoylethanolamide in a Pediatric Population Suffering from Migraine: A Pilot Study
  Papetti L et al. · Pain Research and Management · 2020
  Open-label, no control groupHumans
• Effects of Add-On Ultramicronized N-Palmitol Ethanol Amide in Patients Suffering of Migraine With Aura: A Pilot Study
  Chirchiglia D et al. · Frontiers in Neurology · 2018
  Controlled trialHumans