Combination products
Many commercial products pair palmitoylethanolamide with another active compound. This page lists the published studies of those combinations, grouped by the partner compound.
A study of a combination tests the combination. Its result cannot be assigned to palmitoylethanolamide alone, or to the partner alone, unless the study included separate groups for each. Few do.
48 studies listed.
With 82 patients with rheumatoid arthritis or spondyloarthritis
- Efficacy of a fixed combination of palmitoylethanolamide and acetyl-l-carnitine (PEA+ALC FC) in the treatment of neuropathies secondary to rheumatic diseasesControlled trialHumansWith 82 patients with rheumatoid arthritis or spondyloarthritis and a neuropathy under 12 months old confirmed by electromyography: 42 given the combination on top of standard therapy (18 sciatica, 16 carpal tunnel, 8 lower-limb neuropathy) and 40 matched patients on standard therapy alone (20, 15 and 5)
With acetyl-L-carnitine
- Retrospective Evaluation of L-Acetyl Carnitine and Palmitoylethanolamide as Add-On Therapy in Patients with Fibromyalgia and Small Fiber NeuropathyObservational studyHumansWith acetyl-L-carnitine, Boswellia serrata and vitamins B6 and E
- Unlocking Relief: Investigating the Impact of a Fixed Combination of Acetyl-L-Carnitine and Palmitoylethanolamide on Traumatic Acute Low Back PainObservational studyHumansWith acetyl-L-carnitine, alpha-lipoic acid, Boswellia serrata, vitamins E and B6
- Palmitoylethanolamide and acetyl-L-carnitine act synergistically with duloxetine and pregabalin in fibromyalgia: results of a randomised controlled studyRandomised controlled trialHumansWith acetyl-L-carnitine
- Effect of Ultra-Micronized-Palmitoylethanolamide and Acetyl-l-Carnitine on Experimental Model of Inflammatory PainLaboratory studyOther animalsWith acetyl-L-carnitine
With acetylethanolamine
- N-palmitoylethanolamine and N-acetylethanolamine are effective in asteatotic eczema: results of a randomized, double-blind, controlled study in 60 patientsRandomised controlled trialHumansTopicalWith acetylethanolamine
With adelmidrol (a PEA analogue
- Inhibitory effect of topical adelmidrol on antigen-induced skin wheal and mast cell behavior in a canine model of allergic dermatitisControlled trialDogsTopicalWith adelmidrol (a PEA analogue, tested alone)
With alpha-lipoic acid
- Alpha-Lipoic Acid, Palmitoylethanolamide, Myrrh, and Oxygen-Ozone Therapy Improve Pharmacological Therapy in Acute Painful Lumbosacral Radiculopathy due to Herniated DiscControlled trialHumansWith alpha-lipoic acid and myrrh
- Oxygen-Ozone Therapy Associated with Alpha Lipoic Acid Plus Palmitoylethanolamide and Myrrh versus Ozone Therapy in the Combined Treatment of Sciatic Pain Due to Herniated Discs: Observational Study on 318 PatientsObservational studyHumansWith alpha-lipoic acid and myrrh
- The efficacy of an association of palmitoylethanolamide and alpha-lipoic acid in patients with chronic prostatitis/chronic pelvic pain syndrome: A randomized clinical trialRandomised controlled trialHumansWith alpha-lipoic acid
- Chronic pelvic pain, quality of life and sexual health of women treated with palmitoylethanolamide and alpha-lipoic acidOpen-label, no control groupHumansWith alpha-lipoic acid
With astaxanthin
- A randomized interventional clinical trial assessing the safety and effectiveness of PeaNoc XL tablets in managing joint pain and inflammation in arthritis patientsOpen-label, no control groupHumansWith astaxanthin
With baicalin
- Palmitoylethanolamide/Baicalin Supplementation and Changes in Pain and Sudomotor Function in Type 2 Diabetes: A Retrospective Matched Real-World Cohort StudyObservational studyHumansWith baicalin
- Effectiveness of a nutraceutical agent in the non-surgical periodontal therapy: a randomized, controlled clinical trialRandomised controlled trialHumansWith baicalin
With cannabidiol
- Tolerability profile of topical cannabidiol and palmitoylethanolamide: a compilation of single-centre randomized evaluator-blinded clinical and in vitro studies in normal skinControlled trialHumansTopicalWith cannabidiol
With delta-9-tetrahydrocannabinol (THC)
- A Phase-2 Pilot Study of a Therapeutic Combination of Delta-9-Tetrahydracannabinol and Palmitoylethanolamide for Adults With Tourette's SyndromeOpen-label, no control groupHumansWith delta-9-tetrahydrocannabinol (THC)
With Epilobium
- Serenoa Repens-Lycopene-Selenium and Epilobium-Palmitoylethanolamide-Calendula after transperineal prostate biopsy: a tertiary single center experienceObservational studyHumansWith Epilobium and Calendula (with or without a saw palmetto, lycopene and selenium product)
- Efficacy of Palmitoylethanolamide, Epilobium and Calendula suppositories for the treatment of patients with chronic prostatitis/chronic pelvic pain syndrome type IIIOpen-label, no control groupHumansWith Epilobium and Calendula extract
With Equisetum arvense (horsetail)
- Evaluation of the Clinical Efficacy of a Novel Palmitoylethanolamide–Equisetum arvense Supplement for the Management of Chronic Pain: Findings from a Prospective Clinical TrialOpen-label, no control groupHumansWith Equisetum arvense (horsetail)
With luteolin
- Phase 2 study of palmitoylethanolamide combined with luteoline in frontotemporal dementia patientsRandomised controlled trialHumansWith luteolin
- Palmitoylethanolamide and Luteolin for Postinfectious Olfactory Disorders: How Clinically Meaningful Is Its Effect?Randomised controlled trialHumansWith luteolin
- Efficacy of Palmitoylethanolamide and Luteolin Association on Post-Covid Olfactory Dysfunction: A Systematic Review and Meta-Analysis of Clinical StudiesMeta-analysisHumansWith luteolin
- Treatment of COVID-19 olfactory dysfunction with olfactory training, palmitoylethanolamide with luteolin, or combined therapy: a blinded controlled multicenter randomized trialRandomised controlled trialHumansWith luteolin
- What Is the Role of Palmitoylethanolamide Co-Ultramicronized with Luteolin on the Symptomatology Reported by Patients Suffering from Long COVID? A Retrospective Analysis Performed by a Group of General Practitioners in a Real-Life SettingObservational studyHumansWith luteolin
- Co-ultramicronized palmitoylethanolamide/luteolin normalizes GABAB-ergic activity and cortical plasticity in long COVID-19 syndromeRandomised controlled trialHumansWith luteolin
- Synaptic Effects of Palmitoylethanolamide in Neurodegenerative DisordersReviewHumansOther animalsWith luteolin
- Effect of Ultra-Micronized Palmitoylethanolamide and Luteolin on Olfaction and Memory in Patients with Long COVID: Results of a Longitudinal StudyOpen-label, no control groupHumansWith luteolin
- Ultramicronized Palmitoylethanolamide and Luteolin Supplement Combined with Olfactory Training to Treat Post-COVID-19 Olfactory Impairment: A Multi-Center Double-Blinded Randomized Placebo-Controlled Clinical TrialRandomised controlled trialHumansWith luteolin
- Randomized clinical trial "olfactory dysfunction after COVID-19: olfactory rehabilitation therapy vs. intervention treatment with Palmitoylethanolamide and Luteolin": preliminary resultsRandomised controlled trialHumansWith luteolin
- An Update of Palmitoylethanolamide and Luteolin Effects in Preclinical and Clinical Studies of Neuroinflammatory EventsReviewHumansOther animalsWith luteolin
- Co-ultraPEALut: Role in Preclinical and Clinical Delirium ManifestationsControlled trialHumansOther animalsWith luteolin
- Co-ultramicronized Palmitoylethanolamide/Luteolin in the Treatment of Cerebral Ischemia: from Rodent to ManObservational studyHumansOther animalsWith luteolin
With luteolin; alpha-lipoic acid in two arms
- Persistent COVID-19 parosmia and olfactory loss post olfactory training: randomized clinical trial comparing central and peripheral-acting therapeuticsRandomised controlled trialHumansWith luteolin; alpha-lipoic acid in two arms
With melatonin
- Fixed combination of palmitoylethanolamide and melatonin in preventive therapy of migraine: results from a randomized clinical trialRandomised controlled trialHumansWith melatonin
- A Fixed Combination of Palmitoylethanolamide and Melatonin (PEATONIDE) for the Management of Pain, Sleep, and Disability in Patients with Fibromyalgia: A Pilot StudyOpen-label, no control groupHumansWith melatonin
With polydatin
- Palmitoylethanolamide and polydatin in pediatric irritable bowel syndrome: A multicentric randomized controlled trialRandomised controlled trialHumansWith polydatin
- Micronized Palmitoylethanolamide-Polydatin Reduces the Painful Symptomatology in Patients with Interstitial Cystitis/Bladder Pain SyndromeOpen-label, no control groupHumansWith polydatin
- Effect of ultramicronized-palmitoylethanolamide and co-micronized palmitoylethanolamide/polydatin on chronic pelvic pain and quality of life in endometriosis patients: An open-label pilot studyOpen-label, no control groupHumansWith polydatin
- Randomised clinical trial: the analgesic properties of dietary supplementation with palmitoylethanolamide and polydatin in irritable bowel syndromeRandomised controlled trialHumansWith polydatin
- Effect of palmitoylethanolamide–polydatin combination on chronic pelvic pain associated with endometriosis: Preliminary observationsCase seriesHumansWith polydatin
With probiotics (Bifidobacterium animalis BB12
- Probiotics and palmitoylethanolamide (PEA) for osteoarthritic pain: individual effects in a multiple baseline design studyCase seriesHumansWith probiotics (Bifidobacterium animalis BB12, Lactobacillus rhamnosus LGG, Saccharomyces boulardii)
With quercetin
- A novel composite formulation of palmitoylethanolamide and quercetin decreases inflammation and relieves pain in inflammatory and osteoarthritic pain modelsLaboratory studyOther animalsWith quercetin
With rutin
- The Effects of a Food Supplement, Based on Co-Micronized Palmitoylethanolamide (PEA)–Rutin and Hydroxytyrosol, in Metabolic Syndrome Patients: Preliminary ResultsRandomised controlled trialHumansWith rutin and hydroxytyrosol
With spermidine
- Absorption, anti-inflammatory, antioxidant, and cardioprotective impacts of a novel fasting mimetic containing spermidine, nicotinamide, palmitoylethanolamide, and oleoylethanolamide: A pilot dose-escalation study in healthy young adult menRandomised controlled trialHumansWith spermidine, nicotinamide, oleoylethanolamide
With superoxide dismutase
- Efficacy and Safety of the Combination of Palmitoylethanolamide, Superoxide Dismutase, Alpha Lipoic Acid, Vitamins B12, B1, B6, E, Mg, Zn and Nicotinamide for 6 Months in People with Diabetic NeuropathyRandomised controlled trialHumansWith superoxide dismutase, alpha lipoic acid, B vitamins, vitamin E, magnesium and zinc
With transpolydatin
- Administration of micronized palmitoylethanolamide (PEA)-transpolydatin in the treatment of chronic pelvic pain in women affected by endometriosis: preliminary resultsOpen-label, no control groupHumansWith transpolydatin
- Vestibulodynia: Synergy Between Palmitoylethanolamide + Transpolydatin and Transcutaneous Electrical Nerve StimulationRandomised controlled trialHumansWith transpolydatin
- Effectiveness of the association micronized N-Palmitoylethanolamine (PEA)-transpolydatin in the treatment of chronic pelvic pain related to endometriosis after laparoscopic assessment: a pilot studyRandomised controlled trialHumansWith transpolydatin