Inhibitory effect of topical adelmidrol on antigen-induced skin wheal and mast cell behavior in a canine model of allergic dermatitis
Controlled trialDogsTopicalWith adelmidrol (a PEA analogue, tested alone)
This study tested palmitoylethanolamide together with adelmidrol (a PEA analogue, tested alone). Its results cannot be assigned to palmitoylethanolamide alone. More combination studies.
- Design
- Controlled trial
- Subjects
- 6 Ascaris-hypersensitive beagle dogs, each treated on one flank with adelmidrol and the other with vehicle
- Dose used in the study
- 2 percent adelmidrol emulsion applied topically for 8 days; repeated intradermal antigen challenges
- Duration
- 8 days
- What was measured
- Antigen-induced wheal area on days 4 and 7; skin mast cell counts in biopsies after 8 days
What the authors reported
Wheal areas were smaller on the adelmidrol-treated side on days 4 and 7, and mast cell numbers in biopsies were lower after 8 days of treatment.
Limits of this study
Six dogs in an experimental allergy model, each as its own control. Adelmidrol is a related compound, not palmitoylethanolamide; it is listed because it is sold for the same purposes in veterinary products. Two authors are from Innovet, which makes it.
Source
PubMed 23181761 · doi:10.1186/1746-6148-8-230
Entry checked against the abstract on PubMed on 2026-09-22. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.