Increased levels of palmitoylethanolamide and other bioactive lipid mediators and enhanced local mast cell proliferation in canine atopic dermatitis
Laboratory studyDogs
- Design
- Laboratory study
- Subjects
- Skin biopsies from dogs with atopic dermatitis and from healthy dogs; numbers not in the abstract
- Dose used in the study
- No PEA given. The dogs' own skin PEA was measured
- Duration
- Not applicable
- What was measured
- Lipid mediator levels in skin by mass spectrometry; mast cell number, granule content and in-situ proliferation
What the authors reported
PEA and related lipids were higher in atopic skin than in healthy skin, PEA most of all. Mast cells were more numerous and were proliferating in atopic skin, with less granule content in the perifollicular compartment.
Limits of this study
An observational tissue study. The rise in the skin's own PEA is interpreted by the authors as a protective response, which is a hypothesis. It does not test whether giving PEA helps. One author is from Innovet.
Source
PubMed 24423192 · doi:10.1186/1746-6148-10-21
Entry checked against the abstract on PubMed on 2026-09-22. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.