Laboratory studies
Studies in cultured cells and laboratory animals. They test how palmitoylethanolamide might work.
A laboratory study shows a mechanism. It does not show an effect in patients. Doses in a dish are often far above the levels measured in human blood, and results in mice often fail to carry over to people. How to read a study page.
21 studies listed, newest first.
- Time-controlled online SPE: strategic approach for N-acylethanolamines quantification in complex matricesLaboratory studyHorses
- Chronic palmitoylethanolamide administration via slow-release subcutaneous pellets promotes neuroprotection and mitigates neuroinflammation in the Tg2576 mouse model of Alzheimer's diseaseLaboratory studyOther animals
- Palmitoylethanolamide causes dose-dependent changes in brain function and the lipidomeLaboratory studyOther animals
- Palmitoylethanolamide counteracts high-fat diet-induced gut dysfunction by reprogramming microbiota composition and affecting tryptophan metabolismLaboratory studyOther animals
- Palmitoylethanolamide dampens neuroinflammation and anxiety-like behavior in obese miceLaboratory studyOther animals
- Effect of Ultra-Micronized-Palmitoylethanolamide and Acetyl-l-Carnitine on Experimental Model of Inflammatory PainLaboratory studyOther animalsWith acetyl-L-carnitine
- Palmitoylethanolamide Modulation of Microglia Activation: Characterization of Mechanisms of Action and Implication for Its Neuroprotective EffectsLaboratory studyOther animals
- Palmitoylethanolamide Counteracts Enteric Inflammation and Bowel Motor Dysfunctions in a Mouse Model of Alzheimer's DiseaseLaboratory studyOther animals
- Palmitoylethanolamide: Prenatal Developmental Toxicity Study in RatsLaboratory studyOther animals
- Impaired Duodenal Palmitoylethanolamide Release Underlies Acid-Induced Mast Cell Activation in Functional DyspepsiaLaboratory studyHumansOther animals
- Localization of cannabinoid receptors CB1, CB2, GPR55, and PPAR-alpha in the canine gastrointestinal tractLaboratory studyDogs
- Oral Ultramicronized Palmitoylethanolamide: Plasma and Tissue Levels and Spinal Anti-hyperalgesic EffectLaboratory studyOther animals
- Ultramicronized palmitoylethanolamide counteracts the effects of compound 48/80 in a canine skin organ culture modelLaboratory studyDogs
- A novel composite formulation of palmitoylethanolamide and quercetin decreases inflammation and relieves pain in inflammatory and osteoarthritic pain modelsLaboratory studyOther animalsWith quercetin
- Cannabidiol and palmitoylethanolamide are anti-inflammatory in the acutely inflamed human colonLaboratory studyHumans
- The anti-inflammatory mediator palmitoylethanolamide enhances the levels of 2-arachidonoyl-glycerol and potentiates its actions at TRPV1 cation channelsLaboratory studyHumansDogsOther animals
- Adelmidrol increases the endogenous concentrations of palmitoylethanolamide in canine keratinocytes and down-regulates an inflammatory reaction in an in vitro model of contact allergic dermatitisLaboratory studyDogsOther animals
- Increased levels of palmitoylethanolamide and other bioactive lipid mediators and enhanced local mast cell proliferation in canine atopic dermatitisLaboratory studyDogs
- Effects of palmitoylethanolamide on the cutaneous allergic inflammatory response in Ascaris hypersensitive Beagle dogsLaboratory studyDogs
- Palmitoylethanolamide reduces granuloma-induced hyperalgesia by modulation of mast cell activation in ratsLaboratory studyOther animals
- Effects of palmitoylethanolamide on immunologically induced histamine, PGD2 and TNF-alpha release from canine skin mast cellsLaboratory studyDogs