Palmitoylethanolamide: Prenatal Developmental Toxicity Study in Rats
Laboratory studyOther animals
- Design
- Laboratory study
- Subjects
- Pregnant Wistar rats in dose groups, per OECD Test Guideline 414; group sizes not in the abstract
- Dose used in the study
- 250, 500 or 1,000 mg/kg a day by mouth from day 0 to day 19 of gestation
- Duration
- 19 days of gestation, with caesarean examination on day 20
- What was measured
- Maternal weight, food intake, survival, thyroid function, organ weights and histology; implantation losses, litter size and weight, fetal sex ratio; external, visceral and skeletal fetal abnormalities
What the authors reported
No treatment-related effect on any maternal, reproductive or fetal measure at any dose. The no-observed-adverse-effect level was above 1,000 mg/kg a day.
Limits of this study
A rat study to a regulatory guideline, not a human study. It bears on the absence of human pregnancy data noted on the safety page. Conducted by a contract laboratory for Gencor Pacific, whose staff are co-authors.
Source
PubMed 33576293 · doi:10.1177/1091581820986073
Entry checked against the abstract on PubMed on 2026-09-22. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.