Effect of Ultra-Micronized-Palmitoylethanolamide and Acetyl-l-Carnitine on Experimental Model of Inflammatory Pain
Laboratory studyOther animalsWith acetyl-L-carnitine
This study tested palmitoylethanolamide together with acetyl-L-carnitine. Its results cannot be assigned to palmitoylethanolamide alone. More combination studies.
- Design
- Laboratory study
- Subjects
- Male laboratory rats, 10 per group, with paw inflammation caused by carrageenan
- Dose used in the study
- Ultramicronised palmitoylethanolamide at 2.5 or 5 mg/kg, acetyl-L-carnitine at 2.5 or 100 mg/kg, plain palmitoylethanolamide at 100 mg/kg, and combinations, all by mouth 30 minutes before the injection
- Duration
- 6 hours
- What was measured
- Paw swelling, heat sensitivity, inflammatory cells, mast cells and inflammatory proteins in the paw
What the authors reported
The authors reported that the combined product at 5 mg/kg reduced swelling, heat sensitivity, mast cell infiltration and inflammatory markers, and did so more than either compound alone at higher doses, and more than a 200 mg/kg plain mixture.
Limits of this study
A single acute rat model over 6 hours, which the authors name as a limit. The study was funded by Epitech Group, which supplied the compounds, and the senior author is a co-inventor on Epitech patents covering them.
Source
Entry checked against the full text at the publisher (MDPI) on 2026-09-21. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.