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ALIAmides Update: Palmitoylethanolamide and Its Formulations on Management of Peripheral Neuropathic Pain

D'Amico R, Impellizzeri D, Cuzzocrea S, Di Paola R. International Journal of Molecular Sciences, 2020; 21(15):5330.

ReviewHumansOther animals

Design
Review
What was measured
A narrative review of palmitoylethanolamide and related compounds in nerve pain, covering micronised and ultramicronised forms, combinations and newer derivatives

What the authors reported

The authors describe clinical trials of several formulations in diabetic neuropathy, chemotherapy-related neuropathy, carpal tunnel syndrome, sciatica-type pain and jaw joint pain, and describe safety and tolerability as high. They call for clinical studies of the newer related compounds in people and in animals.

Limits of this study

A narrative review. The page checked gave no study counts or patient numbers, and the funding and conflict statements were not visible.

Source

doi:10.3390/ijms21155330

Entry checked against the full text at the publisher (MDPI) on 2026-09-21. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.