Oxygen-Ozone Therapy Associated with Alpha Lipoic Acid Plus Palmitoylethanolamide and Myrrh versus Ozone Therapy in the Combined Treatment of Sciatic Pain Due to Herniated Discs: Observational Study on 318 Patients
Observational studyHumansWith alpha-lipoic acid and myrrh
This study tested palmitoylethanolamide together with alpha-lipoic acid and myrrh. Its results cannot be assigned to palmitoylethanolamide alone. More combination studies.
- Design
- Observational study
- Subjects
- 318 patients with sciatica from a herniated disc: 165 had CT-guided oxygen-ozone injections alone, 153 had the injections plus the oral supplement
- Dose used in the study
- Oral alpha-lipoic acid plus palmitoylethanolamide plus myrrh; doses not stated in the abstract
- Duration
- Assessed at about 60 days
- What was measured
- Complete pain remission on a modified McNab scale
What the authors reported
Complete remission in 76.4 percent with ozone alone and 77.8 percent with ozone plus the supplement.
Limits of this study
The two groups differed by 1.4 percentage points, which the abstract does not test statistically, yet the conclusion favours the combination. Not randomised, not blinded, one outcome at one time point. Three compounds combined. Authors declare no conflicts.
Source
PubMed 35565111 · doi:10.3390/ijerph19095716
Entry checked against the abstract on PubMed on 2026-09-22. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.