Unlocking Relief: Investigating the Impact of a Fixed Combination of Acetyl-L-Carnitine and Palmitoylethanolamide on Traumatic Acute Low Back Pain
Observational studyHumansWith acetyl-L-carnitine, alpha-lipoic acid, Boswellia serrata, vitamins E and B6
This study tested palmitoylethanolamide together with acetyl-L-carnitine, alpha-lipoic acid, Boswellia serrata, vitamins E and B6. Its results cannot be assigned to palmitoylethanolamide alone. More combination studies.
- Design
- Observational study
- Subjects
- 48 adults with acute low back trauma at one centre
- Dose used in the study
- A fixed-combination supplement taken with conventional therapy; component doses not stated in the abstract
- Duration
- 8 weeks
- What was measured
- Neuropathic Pain Scale and VAS (primary); SF-36 quality of life, NSAID use, adverse events
What the authors reported
Both pain scores fell over 8 weeks, physical SF-36 domains improved and NSAID use fell. Patients with worse baseline symptoms improved most. Emotional SF-36 domains did not change. Adverse events were mild and few.
Limits of this study
Single arm, no control group, open label, 48 patients. Six ingredients given together, so nothing can be assigned to palmitoylethanolamide. Acute back pain improves over 8 weeks on its own. Authors declare no conflicts.
Source
PubMed 40853095 · doi:10.1111/ene.70334
Entry checked against the abstract on PubMed on 2026-09-22. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.