Effectiveness of a nutraceutical agent in the non-surgical periodontal therapy: a randomized, controlled clinical trial
Randomised controlled trialHumansWith baicalin
This study tested palmitoylethanolamide together with baicalin. Its results cannot be assigned to palmitoylethanolamide alone. More combination studies.
- Design
- Randomised controlled trial
- Subjects
- 66 patients with moderate gum disease, in two groups
- Dose used in the study
- A supplement containing palmitoylethanolamide and baicalin, added to standard scaling and root planing. The comparison group had scaling and root planing alone.
- Duration
- 6 months
- What was measured
- Gum attachment level, pocket depth, bleeding on probing, inflammatory markers in gum fluid and pain scores
What the authors reported
The authors reported greater reductions in pocket depth (p = 0.003) and bleeding (p < 0.001) at 6 months in the supplement group, better attachment gains at 30 and 60 days, lower inflammatory markers, and lower pain scores in the two days after treatment.
Limits of this study
No placebo, so the comparison group knew it had no supplement. The dose was not visible on the page checked. The study was funded by the University of Catania, and the authors declared no conflicts.
Source
doi:10.1007/s00784-020-03397-z
Entry checked against the article page at the publisher (Springer) on 2026-09-21. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.