Randomized clinical trial "olfactory dysfunction after COVID-19: olfactory rehabilitation therapy vs. intervention treatment with Palmitoylethanolamide and Luteolin": preliminary results
Randomised controlled trialHumansWith luteolin
This study tested palmitoylethanolamide together with luteolin. Its results cannot be assigned to palmitoylethanolamide alone. More combination studies.
- Design
- Randomised controlled trial
- Subjects
- 12 outpatients with smell loss persisting at least 90 days after a negative COVID-19 test: 7 supplement plus olfactory rehabilitation, 5 olfactory rehabilitation alone
- Dose used in the study
- Daily oral PEA plus luteolin supplement with weekly olfactory rehabilitation, versus twice-daily olfactory rehabilitation alone
- Duration
- 30 days
- What was measured
- Sniffin' Sticks threshold, discrimination and identification at baseline and day 30
What the authors reported
The supplement group improved more on the Sniffin' Sticks score than controls (p = 0.01). Longer time since infection was associated with lower scores. No association with gender.
Limits of this study
Pilot with 12 patients. No placebo and no blinding described in the abstract. The rehabilitation schedule differed between arms (weekly versus twice daily), so the comparison is not of the supplement alone. 30 days only. Same research group as the later, larger trials. Dose not stated in the abstract.
Source
PubMed 34156697 · doi:10.26355/eurrev_202106_26059
Entry checked against the abstract, supplied by Devlin. Dose and blinding were not in the abstract on 2026-09-21. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.