Absorption, anti-inflammatory, antioxidant, and cardioprotective impacts of a novel fasting mimetic containing spermidine, nicotinamide, palmitoylethanolamide, and oleoylethanolamide: A pilot dose-escalation study in healthy young adult men
Randomised controlled trialHumansWith spermidine, nicotinamide, oleoylethanolamide
This study tested palmitoylethanolamide together with spermidine, nicotinamide, oleoylethanolamide. Its results cannot be assigned to palmitoylethanolamide alone. More combination studies.
- Design
- Randomised controlled trial
- Subjects
- 5 healthy young men
- Dose used in the study
- Low, medium or high doses of a four-compound supplement, or wheat flour control, 2 hours after a standard breakfast; PEA dose not stated in the abstract
- Duration
- Single doses with blood samples over 4 hours
- What was measured
- Plasma levels of the four compounds; TNF-alpha and reactive oxygen species from macrophages incubated with the plasma; cholesterol efflux capacity
What the authors reported
Plasma PEA, oleoylethanolamide and 1-methylnicotinamide rose after the supplement in a dose-dependent way. Macrophages exposed to post-supplement plasma released less TNF-alpha and fewer reactive oxygen species.
Limits of this study
Five participants. A pharmacokinetic and laboratory-marker study, not a clinical outcome study. Four compounds given together. Registered NCT05017428.
Source
PubMed 39549554 · doi:10.1016/j.nutres.2024.10.006
Entry checked against the abstract on PubMed on 2026-09-22. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.