Protective Effects of Ultramicronized Palmitoylethanolamide (PEA-um) in Myocardial Ischaemia and Reperfusion Injury in VIVO
Laboratory studyOther animals
- Design
- Laboratory study
- Subjects
- Mice (wild-type and PPAR-alpha knockout) with myocardial ischaemia produced by 30 minutes of coronary artery occlusion followed by 2 hours of reperfusion
- Dose used in the study
- Ultramicronised PEA (PEA-um), 10 mg/kg, given 15 minutes after ischaemia onset and 1 hour after reperfusion
- Duration
- 30 minutes of ischaemia plus 2 hours of reperfusion
- What was measured
- Heart tissue injury, neutrophil infiltration, adhesion molecules (ICAM-1, P-selectin), cytokines (TNF-alpha, IL-1beta), nitrotyrosine and PAR formation, NF-kB expression, and apoptosis markers (Fas-L, Bcl-2); comparison between normal mice and PPAR-alpha knockout mice
What the authors reported
PEA-um reduced heart tissue injury, neutrophil infiltration, adhesion molecule and cytokine levels, nitrotyrosine and PAR formation, NF-kB expression and apoptosis markers in normal mice. This protection was not seen in mice lacking the PPAR-alpha receptor, and ischaemia-reperfusion injury was worse in those knockout mice overall, pointing to a PPAR-alpha-dependent mechanism.
Limits of this study
A mouse model of surgically induced heart ischaemia and reperfusion; it cannot show effect in people. Funding and conflicts not stated in the abstract.
Source
PubMed 26844976 · doi:10.1097/SHK.0000000000000578
Entry checked against the abstract on PubMed on 2026-09-22. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.