Parosmia COVID-19 Related Treated by a Combination of Olfactory Training and Ultramicronized PEA-LUT: A Prospective Randomized Controlled Trial
Randomised controlled trialHumansWith luteolin (co-ultramicronised PEA-LUT), with olfactory training
This study tested palmitoylethanolamide together with luteolin (co-ultramicronised PEA-LUT), with olfactory training. Its results cannot be assigned to palmitoylethanolamide alone. More combination studies.
- Design
- Randomised controlled trial
- Subjects
- Italian patients with post-COVID smell loss and parosmia; number not stated in the abstract
- Dose used in the study
- Daily oral ultramicronised palmitoylethanolamide with luteolin plus olfactory training, or placebo plus olfactory training
- Duration
- 90 consecutive days
- What was measured
- Sniffin' Sticks identification test at baseline and day 90; patient reports of parosmia or aversive smells such as cacosmia or a petrol-type smell.
What the authors reported
PEA-LUT with olfactory training improved quantitative smell loss compared with training alone, but the effect on parosmia was limited. The authors conclude the supplement acts on central neuro-inflammation and has limited or no effect on peripheral damage to the olfactory nerve and epithelium. No numbers are given in the abstract.
Limits of this study
Group sizes, effect sizes and statistics are not given in the abstract. Participants were Italian post-COVID patients only. The authors declare no conflict of interest.
Source
PubMed 37189728 · doi:10.3390/biomedicines11041109
Entry checked against the abstract on PubMed on 2026-09-22. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.