The anti-inflammatory compound palmitoylethanolamide inhibits prostaglandin and hydroxyeicosatetraenoic acid production by a macrophage cell line
Laboratory studyOther animals
- Design
- Laboratory study
- Subjects
- RAW264.7 mouse macrophage cell line, stimulated with lipopolysaccharide and interferon-gamma
- Dose used in the study
- PEA 10 micromol/L
- Duration
- 24 hours
- What was measured
- COX-2 mRNA, prostaglandin D2 and E2, 11- and 15-HETE, linoleic acid-derived oxylipins, and direct effects on COX-2 enzyme activity.
What the authors reported
PEA did not change COX-2 mRNA levels but reduced prostaglandin D2 and E2 and 11- and 15-HETE, an effect that held even when PEA breakdown to palmitic acid was blocked. Linoleic acid-derived oxylipins were unaffected, and PEA had no direct effect on COX-2 oxygenation of arachidonic acid or 2-AG.
Limits of this study
A cell-line study; it cannot show effect in animals or people. Funding and conflicts not stated in the abstract.
Source
PubMed 28357126 · doi:10.1002/prp2.300
Entry checked against the abstract on PubMed on 2026-09-22. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.