Potential Mechanisms Involved in Palmitoylethanolamide-Induced Vasodepressor Effects in Rats
Laboratory studyOther animals
- Design
- Laboratory study
- Subjects
- Wistar pithed rats
- Dose used in the study
- PEA, 0.1 to 3.1 micrograms/kg/min, continuous intravenous infusion, with or without receptor antagonists (NIDA41020, AM630, capsazepine, cannabidiol)
- Duration
- Not stated in the abstract
- What was measured
- Vasopressor responses to sympathetic stimulation or noradrenaline, and resting blood pressure, with and without CB1, CB2, TRPV1 and GPR55 antagonists
What the authors reported
PEA dose-dependently inhibited vasopressor responses to sympathetic stimulation and noradrenaline, and lowered resting blood pressure. These effects were partly blocked by the CB1, TRPV1 or GPR55 antagonists individually, unaffected by the CB2 antagonist, and abolished when all three antagonists were combined.
Limits of this study
A rat pharmacology study; it cannot show effect in people. Funding and conflicts not stated in the abstract.
Source
PubMed 32248195 · doi:10.1159/000506158
Entry checked against the abstract on PubMed on 2026-09-22. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.