Pharmacokinetics of micronized and water dispersible palmitoylethanolamide in comparison with standard palmitoylethanolamide following single oral administration in male Sprague-Dawley rats
Laboratory studyOther animals
- Design
- Laboratory study
- Subjects
- Male Sprague-Dawley rats, single oral dose, multiple formulation groups
- Dose used in the study
- Single oral dose of micronised PEA (10 micrometre grade), micronised PEA (6 micrometre grade), water-dispersible PEA, or standard non-micronised PEA
- Duration
- Single-dose pharmacokinetic study
- What was measured
- Plasma PEA concentration over time by liquid chromatography-tandem mass spectrometry; area under the curve (AUC) and maximum concentration (Cmax) for each formulation.
What the authors reported
All PEA formulations raised total AUC and Cmax compared with non-micronised PEA. Water-dispersible PEA gave an AUC over 16 times higher than non-micronised PEA (p<0.001) and a significantly higher Cmax (p<0.001); the 6-micrometre micronised form also differed significantly (p<0.001), while the 10-micrometre form did not reach significance for Cmax (p=0.060).
Limits of this study
A single-dose rat pharmacokinetic study; it cannot show effect on pain or other symptoms in people or animals treated in practice. The authors declare no conflicts of interest.
Source
PubMed 40686353 · doi:10.4103/ijp.ijp_964_24
Entry checked against the abstract on PubMed on 2026-09-22. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.