Different Dietary N-3 Polyunsaturated Fatty Acid Formulations Distinctively Modify Tissue Fatty Acid and N-Acylethanolamine Profiles
Laboratory studyOther animals
- Design
- Laboratory study
- Subjects
- Rats fed one of six diets differing in n-3 fatty acid source (soybean, linseed, Buglossoides arvensis, fish, Nannochloropsis or Schizochytrium oil)
- Dose used in the study
- Not applicable; palmitoylethanolamide was measured, not given. Diets contained 12% milk fat, 4% soybean oil and 4% test oil
- Duration
- 10 weeks
- What was measured
- Fatty acid and N-acylethanolamine profiles in plasma, liver, brain and adipose tissue.
What the authors reported
Different n-3 sources changed tissue fatty acids and N-acylethanolamine levels in distinct ways. Plasma palmitoylethanolamide and stearoylethanolamide correlated with their liver concentrations, and adipose anandamide and DHEA correlated with plasma levels. The authors concluded that plasma N-acylethanolamine levels may reflect those in specific tissues.
Limits of this study
A rat feeding study measuring PEA levels; it did not give PEA and cannot show effect in people. The authors declare no conflict of interest.
Source
PubMed 33671938 · doi:10.3390/nu13020625
Entry checked against the abstract on PubMed on 2026-09-22. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.