Combination of Rehabilitative Therapy with Ultramicronized Palmitoylethanolamide for Chronic Low Back Pain: An Observational Study
Observational studyHumans
- Design
- Observational study
- Subjects
- Patients with chronic low back pain from multiple lumbar disc herniations (number not stated in the abstract)
- Dose used in the study
- Ultramicronised PEA 600 mg twice daily with rehabilitation and massage for 20 days, then 600 mg once daily for a further 40 days, alongside standard therapy
- Duration
- 60 days total
- What was measured
- Pain intensity (Numeric Rating Scale); quality of life (SF-36); disability (Oswestry Disability Questionnaire)
What the authors reported
Average pain intensity progressively decreased over the study, ending at a level the authors describe as not clinically relevant. This was matched by improvements in physical and mental SF-36 scores and in Oswestry disability scores.
Limits of this study
An observational study without a control group, so it cannot separate the effect of PEA from rehabilitation, massage or natural improvement. The journal's editor-in-chief is a co-author; the other authors report nothing to disclose.
Source
PubMed 31863365 · doi:10.1007/s40122-019-00140-9
Entry checked against the abstract on PubMed on 2026-09-22. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.