Lipid mediator palmitoylethanolamide (PEA) inhibits pathogenic T cell differentiation in vitro and in vivo
Laboratory studyOther animals
- Design
- Laboratory study
- Subjects
- In vitro T cell cultures; mouse models of Toxoplasma gondii infection and ovalbumin-induced allergic rhinitis
- Dose used in the study
- Not stated in the abstract
- Duration
- Not stated in the abstract
- What was measured
- Differentiation of Th1, Th17, Th2 and regulatory T cells in vitro; disease outcomes in a T. gondii infection model and an allergic rhinitis model in vivo
What the authors reported
PEA suppressed differentiation of Th1, Th17 and Th2 cells by inhibiting their master transcription factors, without affecting regulatory T cell differentiation. In mice, PEA increased susceptibility to Toxoplasma gondii infection (where Th1 responses help clear the pathogen) and eased symptoms of ovalbumin-induced allergic rhinitis (where Th2 responses worsen symptoms).
Limits of this study
A cell culture and mouse model study; it cannot show effect in people, and the findings suggest PEA could worsen outcomes in infections needing a Th1 response. The authors declare no competing financial interests.
Source
PubMed 39689644 · doi:10.1016/j.bbrc.2024.151085
Entry checked against the abstract on PubMed on 2026-09-22. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.