Palmitoylethanolamide (PEA) for Prevention of Gastroesophageal Inflammation: Insights from In Vitro Models
Laboratory studyHumansWith Zingiber officinale, Musa × paradisiaca, Opuntia ficus-indica and Olea europaea plant extracts
This study tested palmitoylethanolamide together with Zingiber officinale, Musa × paradisiaca, Opuntia ficus-indica and Olea europaea plant extracts. Its results cannot be assigned to palmitoylethanolamide alone. More combination studies.
- Design
- Laboratory study
- Subjects
- CP-B human esophageal mucosal cell line, exposed to HCl or lipopolysaccharide
- Dose used in the study
- Not stated in the abstract
- Duration
- Not stated in the abstract
- What was measured
- Secretion of IL-1beta, IL-6, IL-10, IL-8 and TNF-alpha (Luminex assay) after HCl or LPS exposure, with and without PEA and plant extracts
What the authors reported
PEA reduced the inflammatory response caused by HCl exposure, and this effect was greater when combined with the plant extracts.
Limits of this study
A human cell line study of acid and LPS exposure; it cannot show effect in people with gastroesophageal reflux disease. The authors declare no conflict of interest.
Source
PubMed 39459521 · doi:10.3390/life14101221
Entry checked against the abstract on PubMed on 2026-09-22. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.