Palmitoylethanolamide attenuates PTZ-induced seizures through CB1 and CB2 receptors
Laboratory studyOther animals
- Design
- Laboratory study
- Subjects
- Male Wistar rats with pentylenetetrazol (PTZ) chemical kindling
- Dose used in the study
- PEA given with or without the CB1 antagonist AM251 or the CB2 antagonist AM630
- Duration
- Not stated in the abstract
- What was measured
- Latency to seizure onset, seizure stage, and latency and duration of the fifth (most severe) seizure stage.
What the authors reported
PEA increased the time to seizure onset and shortened seizure duration after PTZ injection. AM251 had opposite effects depending on dose, AM630 worsened seizures in a dose-dependent way, and combining both antagonists reduced PEA's protective effect, though PEA remained partly effective.
Limits of this study
A rat model of chemically induced seizures; it cannot show effect in people with epilepsy. Funding and conflicts not stated in the abstract.
Source
PubMed 26370914 · doi:10.1016/j.eplepsyres.2015.08.010
Entry checked against the abstract on PubMed on 2026-09-22. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.