Melatonin synergizes with the antinociceptive effect of N-palmitoylethanolamide and paracetamol
Laboratory studyOther animalsWith melatonin and paracetamol
This study tested palmitoylethanolamide together with melatonin and paracetamol. Its results cannot be assigned to palmitoylethanolamide alone. More combination studies.
- Design
- Laboratory study
- Subjects
- Mice tested in the formalin pain test
- Dose used in the study
- Melatonin, paracetamol and palmitoylethanolamide given by intraplantar injection, alone or in combination
- Duration
- Not stated in the abstract
- What was measured
- Antinociceptive effect in both phases of the formalin test, comparing individual concentration-response curves and combinations of melatonin with paracetamol or palmitoylethanolamide.
What the authors reported
All three compounds produced a concentration-dependent antinociceptive effect, with palmitoylethanolamide more potent (EC30 7.4±0.2 mg/paw) than melatonin (EC30 20.5±3.1 mg/paw) or paracetamol (EC30 41.8±2.6 mg/paw). Isobolographic analysis showed melatonin combined with paracetamol or with palmitoylethanolamide synergistically reduced formalin-induced pain, with experimental EC30 values significantly lower than predicted by simple addition.
Limits of this study
A mouse model using intraplantar injection; it cannot show effect in people. Funding and conflicts not stated in the abstract.
Source
PubMed 36199181 · doi:10.1691/ph.2022.2428
Entry checked against the abstract on PubMed on 2026-09-22. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.