Childhood trauma and being at-risk for psychosis are associated with higher peripheral endocannabinoids
Observational studyHumans
- Design
- Observational study
- Subjects
- 33 people at clinical high risk for psychosis and 58 healthy controls
- Dose used in the study
- No palmitoylethanolamide was given; plasma levels were measured
- Duration
- Cross-sectional
- What was measured
- Plasma palmitoylethanolamide and anandamide; childhood trauma history; symptom severity.
What the authors reported
People with both high-risk status and childhood trauma had higher palmitoylethanolamide (p<0.001) and anandamide (p<0.001) than controls and than those without trauma. Palmitoylethanolamide correlated with symptoms and with childhood trauma, and levels rose linearly with the number of risk factors.
Limits of this study
A cross-sectional measurement study; no PEA was given and it cannot say whether levels cause or result from risk. The authors call for larger longitudinal studies. Funding and conflicts not stated in the abstract.
Source
PubMed 31422779 · doi:10.1017/S0033291719001946
Entry checked against the abstract on PubMed on 2026-09-22. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.