Palmitoylethanolamide protects mice against 6-OHDA-induced neurotoxicity and endoplasmic reticulum stress: In vivo and in vitro evidence
Laboratory studyHumansOther animals
- Design
- Laboratory study
- Subjects
- Male mice with unilateral intrastriatal 6-OHDA injection; SH-SY5Y human neuroblastoma cells exposed to 6-OHDA
- Dose used in the study
- PEA 3-30 mg/kg/day subcutaneously in mice; PEA applied to SH-SY5Y cells in vitro
- Duration
- Not stated precisely in the abstract
- What was measured
- Behavioural impairment, striatal tyrosine hydroxylase, iNOS and COX-2, apoptosis markers, superoxide dismutase, endoplasmic reticulum stress markers (GRP78, PERK-eIF2alpha), and SH-SY5Y cell survival.
What the authors reported
This lab study found:
- PEA improved 6-OHDA-induced behavioural impairment and increased striatal tyrosine hydroxylase, indicating preserved dopaminergic neurons.
- It reduced iNOS and COX-2, shifted apoptotic markers toward survival, raised superoxide dismutase, and dampened endoplasmic reticulum stress markers.
- In SH-SY5Y cells, PEA rescued cells from 6-OHDA-induced damage and death.
Limits of this study
A mouse model and a human cell line; it cannot show effect in people with Parkinson's disease. Funding and conflicts not stated in the abstract.
Source
PubMed 27616549 · doi:10.1016/j.phrs.2016.09.004
Entry checked against the abstract on PubMed on 2026-09-22. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.