Palmitoylethanolamide Blunts Amyloid-β42-Induced Astrocyte Activation and Improves Neuronal Survival in Primary Mouse Cortical Astrocyte-Neuron Co-Cultures
Laboratory studyOther animals
- Design
- Laboratory study
- Subjects
- Primary mouse cortical astrocyte-neuron co-cultures
- Dose used in the study
- PEA 0.1 micromol/L, applied to astrocytes 1 hour before and during amyloid-beta42 (0.5 micromol/L) exposure
- Duration
- 24-hour amyloid-beta42 exposure
- What was measured
- Neuronal viability, apoptosis and neurite morphology in astrocyte-neuron co-cultures.
What the authors reported
Astrocytes pre-exposed to amyloid-beta42 lowered neuronal viability, raised apoptotic nuclei counts, reduced MAP-2 positive neuron numbers, and increased neurite aggregation. These effects did not occur when astrocytes were pre-exposed to PEA before amyloid-beta42.
Limits of this study
A mouse cell-culture study; it cannot show effect in animals or people. Funding and conflicts not stated in the abstract.
Source
PubMed 29154284 · doi:10.3233/JAD-170699
Entry checked against the abstract on PubMed on 2026-09-22. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.