Metabotropic Glutamate Receptor 5 and 8 Modulate the Ameliorative Effect of Ultramicronized Palmitoylethanolamide on Cognitive Decline Associated with Neuropathic Pain
Laboratory studyOther animals
- Design
- Laboratory study
- Subjects
- Mice with spared nerve injury neuropathy and sham controls; numbers not stated in the abstract
- Dose used in the study
- Ultramicronised palmitoylethanolamide started after neuropathic pain developed; dose and route not stated in the abstract; given with or without the mGluR5 antagonist MPEP or the mGluR8 antagonist MDCPG
- Duration
- Not stated in the abstract
- What was measured
- Discriminative memory and long-term potentiation in the entorhinal cortex to dentate gyrus pathway.
What the authors reported
Nerve injury reduced memory and LTP. Ultramicronised PEA restored both in injured mice and had no effect in sham mice. MPEP alone improved cognition and restored LTP, but with PEA it blocked the PEA memory effect. MDCPG did not affect memory but prevented the PEA effect on LTP. Both receptors were needed for the PEA effect.
Limits of this study
A mouse model; it cannot show effect in people. Dose, route, duration and animal numbers are not in the abstract. The authors declare no conflict of interest.
Source
PubMed 30970677 · doi:10.3390/ijms20071757
Entry checked against the abstract on PubMed on 2026-09-22. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.