Palmitoylethanolamide, a naturally occurring lipid, is an orally effective intestinal anti-inflammatory agent
Laboratory studyOther animals
- Design
- Laboratory study
- Subjects
- Mice given dinitrobenzenesulfonic acid (DNBS) into the colon to induce colitis
- Dose used in the study
- PEA, 1 mg/kg, given into the abdomen and/or by mouth
- Duration
- Not stated in the abstract
- What was measured
- Inflammatory markers and histology, intestinal permeability, colon cell proliferation, colonic PEA and endocannabinoid levels, and receptor and enzyme mRNA expression, with and without CB2, GPR55, PPAR-alpha or TRPV1 blockers
What the authors reported
This lab study found:
- DNBS caused colon inflammation, increased intestinal permeability, and raised colonic PEA and endocannabinoid levels.
- Oral and abdominal PEA reduced inflammation and permeability and increased colon cell proliferation and TRPV1 and CB1 receptor expression.
- PEA's anti-inflammatory effect was reduced or removed by CB2, GPR55 or PPAR-alpha blockers, and increased further by a TRPV1 blocker.
Limits of this study
A mouse model of chemically induced colitis; it cannot show effect in people with inflammatory bowel disease. Funding and conflicts not stated in the abstract.
Source
PubMed 25205418 · doi:10.1111/bph.12907
Entry checked against the abstract on PubMed on 2026-09-22. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.