Role of palmitoylethanolamide (PEA) in depression: Translational evidence
ReviewHumansOther animals
- Design
- Review
- Subjects
- Narrative review
- Dose used in the study
- Not applicable
- Duration
- Not applicable
- What was measured
- Receptor targets, animal models of depression, and the one randomised trial of palmitoylethanolamide added to citalopram
What the authors reported
Antidepressant-like activity appears in animal models. A randomised double-blind trial (Ghazizadeh-Hashemi 2018) showed fast antidepressant action when palmitoylethanolamide was added to citalopram, though the authors note the limited number of studies.
Limits of this study
Narrative review resting on one small add-on trial in people. Independent academic authors (Montreal, Cagliari, Milan).
Source
PubMed 30391203 · doi:10.1016/j.jad.2018.10.117
Entry checked against the abstract on PubMed on 2026-09-22. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.