N-Acylphosphatidylethanolamines and N-acylethanolamines increase in saliva upon food mastication: the influence of the individual nutritional status and fat type in food
Controlled trialHumans
- Design
- Controlled trial
- Subjects
- 25 healthy adults: 12 normal weight (9 women, 30.4 years) and 13 obese (8 women, 35.5 years), randomised crossover
- Dose used in the study
- No palmitoylethanolamide supplement; biscuits with 10% olive oil, 10% palm oil or 10% paraffin oil were chewed and salivary PEA measured
- Duration
- Single fasting sessions
- What was measured
- Salivary N-acylphosphatidylethanolamines and the N-acylethanolamines LEA, OEA and PEA by LC-high-resolution mass spectrometry in unstimulated saliva, after chewing parafilm, and after chewing each biscuit
What the authors reported
The study found:
- Obese participants had higher salivary NAPEs (280.0 vs 121.8 ng/mL, p=0.015) and NAEs (10.8 vs 4.8 ng/mL, p=0.002) than normal-weight participants.
- Chewing parafilm lowered OEA and PEA.
- Biscuit chewing raised NAPEs, LEA and OEA but not PEA.
- PEA was unchanged in normal-weight participants and fell with control and palm-oil biscuits in obese participants.
Limits of this study
A small crossover study of 25 people measuring saliva after single chewing sessions; it does not test PEA as a supplement. Funding and conflicts not stated in the abstract.
Source
PubMed 32232261 · doi:10.1039/c9fo02205h
Entry checked against the abstract on PubMed on 2026-09-22. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.