Diurnal Profiles of N-Acylethanolamines in Goldfish Brain and Gastrointestinal Tract: Possible Role of Feeding
Laboratory studyOther animals
- Design
- Laboratory study
- Subjects
- Goldfish (Carassius auratus); numbers not stated in the abstract
- Dose used in the study
- No palmitoylethanolamide was given; tissue levels were measured
- Duration
- A 24-hour cycle, fed and fasted
- What was measured
- Oleoylethanolamide, palmitoylethanolamide, stearoylethanolamide and NAPE precursors in gut and brain; expression of nape-pld, faah, ppar-alpha and the clock genes bmal1a and rev-erb-alpha.
What the authors reported
This laboratory study found:
- Gut NAE levels fluctuated over the day with a sharp rise after feeding that was absent in fasted fish, while brain levels showed no periprandial change.
- Ppar-alpha expression had a daily rhythm in intestine and liver.
- Clock genes also showed daily rhythms, with bmal1a rising after feeding.
- All components of the NAE system were present in fish.
Limits of this study
A fish physiology study measuring endogenous levels; no PEA was given and it cannot show effect in people or mammals. Funding and conflicts not stated in the abstract.
Source
PubMed 31133788 · doi:10.3389/fnins.2019.00450
Entry checked against the abstract on PubMed on 2026-09-22. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.