Intestinal Disorder in Zebrafish Larvae (Danio rerio): The Protective Action of N-Palmitoylethanolamide-oxazoline

Davide Di Paola, Sabrina Natale, Carmelo Iaria, Marika Cordaro, Rosalia Crupi, Rosalba Siracusa, Ramona D'Amico, Roberta Fusco, Daniela Impellizzeri, Salvatore Cuzzocrea, Nunziacarla Spanò, Enrico Gugliandolo, Alessio Filippo Peritore. Life (Basel). 2022 Jan 16;12(1):125.

Laboratory studyOther animalsWith N-palmitoylethanolamide-oxazoline (PEA-OXA, a PEA analogue, tested alone)

This study tested palmitoylethanolamide together with N-palmitoylethanolamide-oxazoline (PEA-OXA, a PEA analogue, tested alone). Its results cannot be assigned to palmitoylethanolamide alone. More combination studies.

Design

Laboratory study

Subjects

Zebrafish (Danio rerio) larvae exposed to dextran sulphate sodium (DSS) to induce enterocolitis

Dose used in the study

PEA-OXA at 10 mg/L in water, following repeated exposure to 0.25% DSS

Duration

Not stated in the abstract

What was measured

Gut structure and mucus production, and expression of inflammatory and endoplasmic-reticulum stress genes in the intestine

What the authors reported

Repeated DSS exposure caused gut alteration with increased mucus production and increased inflammatory and endoplasmic-reticulum stress gene expression. PEA-OXA at 10 mg/L decreased DSS-induced gut damage and mucus production and reduced inflammatory and ER stress-related gene expression.

Limits of this study

A zebrafish larval model; it cannot show effect in people or mammals. One author is a coinventor on an Epitech Group patent related to PEA-metabolising enzymes, unrelated to this study.

Source

PubMed 35054518 · doi:10.3390/life12010125

Entry checked against the abstract on PubMed on 2026-09-22. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.