α-Acylamino-β-lactone N-Acylethanolamine-hydrolyzing Acid Amidase Inhibitors Encapsulated in PLGA Nanoparticles: Improvement of the Physical Stability and Protection of Human Cells from Hydrogen Peroxide-Induced Oxidative Stress
Laboratory studyHumansWith URB866 (a NAAA inhibitor that raises the body's own palmitoylethanolamide), loaded in PLGA nanoparticles; PEA itself was not given
This study tested palmitoylethanolamide together with URB866 (a NAAA inhibitor that raises the body's own palmitoylethanolamide), loaded in PLGA nanoparticles; PEA itself was not given. Its results cannot be assigned to palmitoylethanolamide alone. More combination studies.
- Design
- Laboratory study
- Subjects
- Various human cell lines exposed to hydrogen peroxide
- Dose used in the study
- URB866 at 25 micromolar in cell culture
- Duration
- Not stated in the abstract
- What was measured
- Size, stability, drug retention and photostability of URB866-loaded nanoparticles; antioxidant protection of cells against hydrogen peroxide.
What the authors reported
The nanoparticles had a single-size population, were stable over time and temperature, retained the compound well and improved its photostability compared with the free molecule. At 25 micromolar they showed a better antioxidant profile on several cell lines.
Limits of this study
A formulation and cell culture study; it cannot show effect in people. Palmitoylethanolamide was not tested; the compound blocks the enzyme that breaks PEA down. The authors declare no conflict of interest.
Source
PubMed 35453371 · doi:10.3390/antiox11040686
Entry checked against the abstract on PubMed on 2026-09-22. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.