Pharmacological Blockade of PPARα Exacerbates Inflammatory Pain-Related Impairment of Spatial Memory in Rats
Laboratory studyOther animals
- Design
- Laboratory study
- Subjects
- Rats with or without chronic inflammatory pain induced by Complete Freund's Adjuvant
- Dose used in the study
- Intraperitoneal PPAR antagonists (GW6471, GSK0660, GW9662) or palmitoylethanolamide; doses not stated in the abstract
- Duration
- Not stated in the abstract
- What was measured
- Anxiety-like behaviour (elevated plus maze, open field, light-dark box) and memory (novel object recognition); hippocampal N-acylethanolamine levels.
What the authors reported
This laboratory study found:
- Rats with inflammatory pain showed impaired recognition and spatial memory, and blocking PPAR-alpha worsened spatial memory further.
- Oleoylethanolamide was higher in the dorsal hippocampus of the pain group.
- Pain did not change innate anxiety responses.
- The abstract reports no specific effect of palmitoylethanolamide treatment.
Limits of this study
A rat model; it cannot show effect in people. PEA doses and PEA-specific results are not given in the abstract. The authors declare no conflict of interest and state that funders had no role.
Source
PubMed 34072060 · doi:10.3390/biomedicines9060610
Entry checked against the abstract on PubMed on 2026-09-22. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.