Longitudinal course of endocannabinoids and N-acylethanolamines in hair of mothers and their children in the first year postpartum: investigating the relevance of maternal childhood maltreatment experiences
Observational studyHumans
- Design
- Observational study
- Subjects
- 170 mothers and 150 children, with and without maternal childhood maltreatment
- Dose used in the study
- No palmitoylethanolamide was given; hair levels were measured
- Duration
- Two timepoints: late pregnancy and 10 to 12 months postpartum
- What was measured
- Anandamide, 2-AG/1-AG, stearoylethanolamide, oleoylethanolamide and palmitoylethanolamide in 3 cm hair strands from mothers and children; maternal childhood maltreatment by questionnaire.
What the authors reported
This observational study found:
- In mothers, 2-AG/1-AG rose and stearoylethanolamide fell from late pregnancy to one year postpartum.
- Maternal maltreatment was linked to lower stearoylethanolamide in late pregnancy but not a year later.
- In children, 2-AG/1-AG rose while stearoylethanolamide, oleoylethanolamide and PEA fell.
- Maternal maltreatment was not consistently linked to eCB levels in children's hair.
Limits of this study
An observational study of hair levels. It did not give PEA and shows association only, not cause. The authors declare no commercial or financial conflicts.
Source
PubMed 37198936 · doi:10.1017/S0033291723001204
Entry checked against the abstract on PubMed on 2026-09-22. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.