Opposite Effects of Neuroprotective Cannabinoids, Palmitoylethanolamide, and 2-Arachidonoylglycerol on Function and Morphology of Microglia
Laboratory studyOther animalsWith 2-arachidonoylglycerol (2-AG, tested alongside PEA, not as a fixed combination product)
This study tested palmitoylethanolamide together with 2-arachidonoylglycerol (2-AG, tested alongside PEA, not as a fixed combination product). Its results cannot be assigned to palmitoylethanolamide alone. More combination studies.
- Design
- Laboratory study
- Subjects
- Organotypic hippocampal slice cultures with excitotoxic lesion, and primary microglial cell cultures stimulated with lipopolysaccharide
- Dose used in the study
- PEA, 2-AG, or the combination, applied to cultures; concentrations not stated in the abstract
- Duration
- Not stated in the abstract
- What was measured
- Number of damaged neurons after excitotoxic lesion; microglial nitric oxide production, ramification index, proliferation and PPAR-alpha distribution.
What the authors reported
PEA or 2-AG alone reduced neuronal damage after excitotoxic lesion, but combining them removed this protective effect, independent of microglial cells. PEA and 2-AG had opposite effects on microglial ramification and nitric oxide production; microglial proliferation and PPAR-alpha expression were unchanged, though PPAR-alpha distribution shifted.
Limits of this study
A cell- and tissue-culture study; it cannot show effect in people or animals. Funding and conflicts not stated in the abstract.
Source
PubMed 31787870 · doi:10.3389/fnins.2019.01180
Entry checked against the abstract on PubMed on 2026-09-22. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.