Palmitoylethanolamide prevents neuroinflammation, reduces astrogliosis and preserves recognition and spatial memory following induction of neonatal anoxia-ischemia
Laboratory studyOther animals
- Design
- Laboratory study
- Subjects
- 7-day-old rats subjected to neonatal anoxia-ischemia (AI)
- Dose used in the study
- PEA or oleoylethanolamide (OEA), 2 or 10 mg/kg; route not stated
- Duration
- Behavioural tests and immunohistochemistry at 30 days of age
- What was measured
- Locomotion, recognition and spatial memory, neuroinflammation, astrogliosis and PPARalpha expression in the hippocampus.
What the authors reported
Neonatal AI reduced locomotion and impaired recognition and spatial memory, with more neuroinflammation and astrogliosis and less PPARalpha expression. PEA treatment prevented neuroinflammation, reduced astrogliosis and preserved cognitive function.
Limits of this study
A neonatal rat model of anoxia-ischemia; it cannot show effect in people. Funding and conflicts not stated in the abstract.
Source
PubMed 30058012 · doi:10.1007/s00213-018-4982-9
Entry checked against the abstract on PubMed on 2026-09-22. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.