Cannabidiol Effects on Phospholipid Metabolism in Keratinocytes from Patients with Psoriasis Vulgaris
Laboratory studyHumansWith cannabidiol (tested alone; PEA was a measured lipid)
This study tested palmitoylethanolamide together with cannabidiol (tested alone; PEA was a measured lipid). Its results cannot be assigned to palmitoylethanolamide alone. More combination studies.
- Design
- Laboratory study
- Subjects
- Keratinocytes isolated from the skin of psoriasis patients and healthy volunteers, with or without UVA/UVB irradiation
- Dose used in the study
- Cannabidiol in culture; concentration not stated in the abstract
- Duration
- Not stated in the abstract
- What was measured
- Reactive oxygen species, thioredoxin system, vitamins A and E, lipid peroxidation products, anandamide and palmitoylethanolamide levels, CB1 and CB2 receptor expression, and transporter activity.
What the authors reported
This laboratory study found:
- CBD reduced oxidative imbalance in irradiated keratinocytes from healthy people but tended to raise oxidative and inflammatory state in cells from psoriasis patients.
- Anandamide fell in healthy cells and rose in patient cells with CBD, while palmitoylethanolamide fell in both groups.
- CBD raised CB1 expression mainly in patient cells and CB2 in both, and normalised MDR and BCRP transporter activity.
Limits of this study
A cell culture study of cannabidiol; PEA was measured, not given. Results in cells cannot show effect in people. The authors declare no conflicts of interest.
Source
PubMed 32121131 · doi:10.3390/biom10030367
Entry checked against the abstract on PubMed on 2026-09-22. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.