N-Acylethanolamine acid amidase (NAAA) exacerbates psoriasis inflammation by enhancing dendritic cell (DCs) maturation
Laboratory studyHumansOther animals
- Design
- Laboratory study
- Subjects
- Psoriasis patients' samples and imiquimod-induced psoriasis in mice, including NAAA transgenic and knockout mice
- Dose used in the study
- No palmitoylethanolamide was given; the NAAA inhibitor F96 was applied locally, dose not stated in the abstract
- Duration
- Not stated in the abstract
- What was measured
- NAAA expression in psoriasis; psoriasis development with NAAA overexpression, deletion or inhibition; dendritic cell maturation; PEA-PPAR-alpha signalling, p65 acetylation and IL-10 production.
What the authors reported
The study found:
- NAAA was raised in psoriasis patients and in the mouse model.
- NAAA overexpression sped up psoriasis, while NAAA deletion or the inhibitor F96 lessened it, with NAAA in dendritic cells, not other cell types, driving the effect.
- NAAA degraded PEA, reducing PEA-PPAR-alpha signalling, lowering IL-10 and promoting dendritic cell maturation.
Limits of this study
A mouse and tissue study; it cannot show effect in people treated in practice. PEA was not given. Several authors are co-inventors on patents covering NAAA inhibitors.
Source
PubMed 36244543 · doi:10.1016/j.phrs.2022.106491
Entry checked against the abstract on PubMed on 2026-09-22. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.