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Palmitoylethanolamide, a Natural Retinoprotectant: Its Putative Relevance for the Treatment of Glaucoma and Diabetic Retinopathy

Keppel Hesselink JM, Costagliola C, Fakhry J, Kopsky DJ. J Ophthalmol. 2015;2015:430596.

ReviewHumans

Design
Review
Subjects
Narrative review
Dose used in the study
Up to 1.8 g a day in the trials cited
Duration
Not applicable
What was measured
The case for palmitoylethanolamide in glaucoma, diabetic retinopathy and uveitis, drawing on the eye trials and the wider trial record

What the authors reported

Palmitoylethanolamide has been tested in at least nine double-blind placebo-controlled studies, two in glaucoma, and found safe and effective up to 1.8 g a day, the authors state. They name the products sold in Italy and the Netherlands for this use.

Limits of this study

A promotional tone: the abstract names commercial products. The lead author runs a clinic that prescribes the compound and has a commercial interest in one product. The glaucoma trials it relies on are small and are listed on this site with their limits.

Source

PubMed 26664738 · doi:10.1155/2015/430596

Entry checked against the abstract on PubMed on 2026-09-22. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.