Effect of intravenous, perioperative-administered lidocaine on serum levels of endocannabinoids and related N-acylethanolamines in children
Controlled trialHumans
- Design
- Controlled trial
- Subjects
- 44 children having extensive spinal surgery (23 given intravenous lidocaine, 21 not) and 23 healthy matched children
- Dose used in the study
- No palmitoylethanolamide was given; intravenous lidocaine as a co-analgesic during anaesthesia
- Duration
- Blood sampled before surgery, immediately after, at 6 hours and the next morning
- What was measured
- Serum anandamide, 2-arachidonoylglycerol, palmitoylethanolamide and oleoylethanolamide by liquid chromatography-mass spectrometry.
What the authors reported
Levels were similar in controls and patients before surgery. After surgery the lidocaine group had higher anandamide and lower 2-AG than the non-lidocaine group. Palmitoylethanolamide peaked in the lidocaine group 6 hours after surgery and was higher than in the non-lidocaine group at that time (P=0.0003).
Limits of this study
A measurement study of endogenous levels in children; no PEA was given. Allocation to lidocaine is not described as randomised in the abstract. Funding and conflicts not stated in the abstract.
Source
PubMed 31630508 · doi:10.23736/S0375-9393.19.13703-0
Entry checked against the abstract on PubMed on 2026-09-22. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.