An Observational Study of the Application of a Topical Cannabinoid Gel on Sensitive Dry Skin
Observational studyHumansTopical
- Design
- Observational study
- Subjects
- 20 people with self-reported eczema enrolled; 16 completed
- Dose used in the study
- A topical cannabidiol (CBD) gel; palmitoylethanolamide was not given. Amount not stated
- Duration
- 2 weeks
- What was measured
- Patient Oriented Eczema Measure (POEM) and the emotional domain of the Quality of Life Hand Eczema Questionnaire, by online questionnaire.
What the authors reported
The observational study found:
- Mean POEM fell from 16 to 8.25 at two weeks (P<0.0007), and the emotional QOLHEQ score from 20.9 to 8.375 (P<0.004).
- 67% reported less itch and 50% felt their eczema improved by more than 60%.
- The abstract mentions palmitoylethanolamide only as background, citing earlier reports of effect on itch, excoriation and redness in atopic dermatitis.
Limits of this study
This study tested topical CBD, not palmitoylethanolamide. It was small, uncontrolled, unblinded and based on self-report with 4 dropouts. Funding and conflicts not stated in the abstract.
Source
PubMed 33346512 · doi:10.36849/JDD.2020.5464
Entry checked against the abstract on PubMed on 2026-09-22. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.