Palmitoylethanolamide reduces inflammation and itch in a mouse model of contact allergic dermatitis
Laboratory studyOther animals
- Design
- Laboratory study
- Subjects
- Female C57BL/6J mice with DNFB-induced contact allergic dermatitis (CAD)
- Dose used in the study
- PEA 5 mg/kg intraperitoneally, at each of three allergen challenges and for two more days
- Duration
- 19-day sensitization/challenge protocol, itch assessed 48 hours after the final challenge
- What was measured
- Ear thickness increase, mast cell numbers, VEGF/Flk-1 expression, scratching behaviour, and the roles of CB2 and PPAR-alpha receptors.
What the authors reported
PEA reduced the ear thickness increase, mast cell numbers, and VEGF/Flk-1 expression in the late stage of contact allergic dermatitis, and reduced scratching 48 hours after the final challenge. The anti-inflammatory effect was reversed by a CB2 antagonist but not a PPAR-alpha antagonist; the anti-itch effect was reversed by both.
Limits of this study
A mouse model of contact allergic dermatitis; it cannot show effect in people. Funding and conflicts not stated in the abstract.
Source
PubMed 27720681 · doi:10.1016/j.ejphar.2016.10.005
Entry checked against the abstract on PubMed on 2026-09-22. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.