N-Acylethanolamine Acid Amidase (NAAA): Structure, Function, and Inhibition
ReviewHumansOther animals
- Design
- Review
- Subjects
- Not stated in the abstract
- Dose used in the study
- Not stated in the abstract
- Duration
- Not stated in the abstract
- What was measured
- How NAAA controls palmitoylethanolamide signalling at PPAR-alpha, its structure, and inhibition by covalent and non-covalent agents, and the potential of NAAA-targeting drugs
What the authors reported
NAAA is described as a lysosomal cysteine hydrolase in immune cells that deactivates PEA, with NAAA-regulated PEA signalling at PPAR-alpha presented as a control point for starting and resolving inflammation. The structural basis of inhibition is reviewed. No new data or numbers are given.
Limits of this study
A perspective review, not a trial. Funding and conflicts not stated in the abstract, though Daniele Piomelli holds NAAA inhibitor patent applications noted in related records.
Source
PubMed 32191459 · doi:10.1021/acs.jmedchem.0c00191
Entry checked against the abstract on PubMed on 2026-09-22. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.