Antiepileptogenic Effect of Subchronic Palmitoylethanolamide Treatment in a Mouse Model of Acute Epilepsy
Laboratory studyOther animals
- Design
- Laboratory study
- Subjects
- Mice with kainic acid-induced acute seizures
- Dose used in the study
- PEA given by intraperitoneal injection, acute and subchronic; exact mg/kg not stated in the abstract
- Duration
- Endocannabinoid and eicosanoid levels tracked over 180 minutes post-seizure; subchronic dosing also tested
- What was measured
- Seizure intensity, neuroprotection, and hippocampal/plasma endocannabinoid and eicosanoid levels, compared with FAAH blockade
What the authors reported
Subchronic PEA significantly lessened seizure intensity, promoted neuroprotection, and changed plasma and hippocampal endocannabinoid and eicosanoid levels after kainic acid-induced seizures in mice.
Limits of this study
A mouse model of acute seizures; it cannot show effect in people with epilepsy. Funding and conflicts not stated in the abstract.
Source
PubMed 29593494 · doi:10.3389/fnmol.2018.00067
Entry checked against the abstract on PubMed on 2026-09-22. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.