Interaction between the protective effects of cannabidiol and palmitoylethanolamide in experimental model of multiple sclerosis in C57BL/6 mice
Laboratory studyOther animalsWith cannabidiol
This study tested palmitoylethanolamide together with cannabidiol. Its results cannot be assigned to palmitoylethanolamide alone. More combination studies.
- Design
- Laboratory study
- Subjects
- C57BL/6 mice given myelin oligodendrocyte glycoprotein (MOG) to induce experimental autoimmune encephalomyelitis, a multiple sclerosis model
- Dose used in the study
- Cannabidiol 5 mg/kg, PEA 5 mg/kg, or both together, from disease onset
- Duration
- Not stated in the abstract
- What was measured
- Neurobehavioural disease scores, immune cell infiltration, demyelination, axon damage and inflammatory cytokine expression
What the authors reported
Cannabidiol or PEA given alone each reduced disease severity scores, inflammation, demyelination, axon damage and cytokine expression. Giving cannabidiol and PEA together was less effective than either drug alone, indicating an antagonistic interaction between the two in this model.
Limits of this study
A mouse model of induced autoimmune brain and spinal cord inflammation; it cannot show effect in people with multiple sclerosis. Funding and conflicts not stated in the abstract.
Source
PubMed 25637488 · doi:10.1016/j.neuroscience.2015.01.030
Entry checked against the abstract on PubMed on 2026-09-22. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.