Relative Deficiency of Anti-Inflammatory N-Acylethanolamines Compared to Prostaglandins in Oral Lichen Planus
Observational studyHumans
- Design
- Observational study
- Subjects
- Oral mucosa biopsies from patients with oral lichen planus and healthy controls, in two patient cohorts; numbers not stated in the abstract
- Dose used in the study
- Not applicable; palmitoylethanolamide was measured, not given
- Duration
- Not stated in the abstract
- What was measured
- Expression of PTGS2 (COX-2) and NAPEPLD (an N-acylethanolamine synthesis enzyme); the ratio of COX-2-derived prostaglandins to palmitoylethanolamide in tissue
What the authors reported
PTGS2 was about 4-fold higher in oral lichen planus than in controls, and the PTGS2 to NAPEPLD ratio was significantly raised. In a second cohort the ratio of prostaglandins to PEA was also increased. The authors concluded there is an imbalance between prostaglandins and PEA in this condition.
Limits of this study
A tissue biopsy study measuring the body's own PEA; it did not test PEA treatment. Sample sizes are not stated in the abstract. The authors declare no conflict of interest.
Source
PubMed 33172176 · doi:10.3390/biomedicines8110481
Entry checked against the abstract on PubMed on 2026-09-22. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.