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Endocannabinoid and steroid analysis in infant and adult nails by LC-MS/MS

Tanja Restin, Nastassja Byland, Clarissa D Voegel, Pearl La Marca-Ghaemmaghami, Markus R Baumgartner, Dirk Bassler, Thomas Kraemer, Tina M Binz. Anal Bioanal Chem. 2022 Aug;414(20):6201-6211.

Observational studyHumans

Design
Observational study
Subjects
57 nail samples from newborns (1 month), children (1 to 10 years) and adults (up to 43 years)
Dose used in the study
Not stated in the abstract; no treatment was given
Duration
Not stated in the abstract
What was measured
Validation of an LC-MS/MS method to measure four endocannabinoids (including palmitoylethanolamide) and five steroid hormones in nail samples

What the authors reported

This observational study found:

  • The method was validated.
  • Matrix effects appeared mainly for 2-AG.
  • Sample weights below 5 mg gave variable results for some analytes, but PEA and progesterone could be measured accurately below that weight.
  • The authors report this as the first simultaneous measurement of steroids and endocannabinoids in infant and adult nails.

Limits of this study

A laboratory method study; it measured natural palmitoylethanolamide levels and did not test PEA as a treatment. Small pilot cohort. The authors declare no competing interests.

Source

PubMed 35781588 · doi:10.1007/s00216-022-04189-y

Entry checked against the abstract on PubMed on 2026-09-22. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.