Investigating the Long-Term Effect of an Interdisciplinary Multimodal Rehabilitation Program on Levels of Bioactive Lipids and Telomerase Activity in Blood from Patients with Chronic Pain
Open-label, no control groupHumans
- Design
- Open-label, no control group
- Subjects
- 18 patients with complex chronic pain taking part in a rehabilitation programme
- Dose used in the study
- Not stated in the abstract; no palmitoylethanolamide was given
- Duration
- Six-month follow-up
- What was measured
- Plasma AEA, 2-AG, palmitoylethanolamide, OEA, SEA and telomerase activity, plus self-reported pain, psychological distress and physical activity before the programme and at six months.
What the authors reported
This open-label study found:
- Pain intensity fell and SEA levels rose at six months, and the two changes were correlated.
- AEA was inversely correlated with physical activity.
- 2-AG and telomerase activity were correlated at follow-up.
- No change in palmitoylethanolamide was reported.
Limits of this study
A small exploratory study with no control group; it measured natural palmitoylethanolamide and did not test PEA as a treatment. The authors declare no conflict of interest.
Source
PubMed 35268382 · doi:10.3390/jcm11051291
Entry checked against the abstract on PubMed on 2026-09-22. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.